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doi: 10.1177/2042018821989238 167 GaddeKMAtkinsKD
The article says combination therapy is typically considered when glycemic control is inadequate on GLP-1 monotherapy, or when cost, adherence or side effects favor adding an oral DPP-4 instead of increasing the GLP-1 amount
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This is particularly relevant given the intersection of estrogen signaling, GLP-1 pathways, and genetic risk factors related to APOE4 status
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