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[6] Factors that may prolong or worsen symptoms include: Rapid dose escalation beyond what the individual gut can tolerate High-fat, high-sugar, or heavily processed dietary intake Concurrent use of medications that can independently cause loose stools, such as metformin, magnesium-containing preparations, or orlistat a clinician should review the full medication list if diarrhoea is persistent Underlying gastrointestinal conditions such as inflammatory bowel disease or coeliac disease Real-world duration of symptoms may differ from controlled trial settings

Notably, elevated plasma biomarker concentrations are linked to reduced white matter quality (Figure 3A and B), showing brain regions where GFAP and, to a smaller extent, NfL concentrations are amplified, affecting neurite density reduction and neuronal health processes

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These medications undergo rigorous FDA review, ensuring consistent dosing and safety data established through expansive clinical trials