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Intestinal microorganisms metabolize TML into trimethyl-5-aminovaleric acid (TMAVA), which can competitively inhibit the binding of -BB to BBD, thereby inhibiting carnitine biosynthesis and FAO in the liver, promoting steatosis and aggravating fatty liver [250]

Intracellular iron accumulation has been shown to drive macrophage polarization toward the M2 phenotype, which is associated with the secretion of anti-inflammatory cytokines, promotion of neovascularization, and suppression of anti-tumor immune responses [83]

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It is a well established form of collagen induction therapy used across dermatology, not a trend treatment

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