Effects of dexmedetomidine pretreatment, posttreatment, and whole-course pumping on myocardial damage during cardiac valve replacement
(See Holford et al, 2013, for parameters in neonates and children.) Knowing the relationship between dose, drug concentration, and effects allows the clinician to take into account the various pathologic and physiologic features of a particular patient that make him or her different from the average individual in responding to a drug
Running out mid-protocol disrupts consistency
For example, a common observation is that additives that partition to the membrane-water interface, i.e., to the headgroup region of lipid membranes, tend to disrupt lipid packing and subsequently lower the phase transition temperatures, decrease the bending moduli, and increase lipid mobility
Flier, J