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For example, different actions of GLP-1 receptor agonists such as delaying gastric emptying which leads to a prolonged feeling of fullness and reducing food intake lead to significant weight loss ( Endogenous GLP-1 has a short half-life since it is in 1-2 minutes degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

When significant muscle is lost during weight loss, resting metabolic rate falls faster and further than fat loss alone would cause

Additionally, your metabolic rate slows slightly as you weigh less, meaning you burn fewer calories at resta process called metabolic adaptation that is entirely normal and expected