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For liver-specific genetic deletions, mice were injected via the tail vein with 2.510 11 GC of AAV-TBG-Cre (Addgene, 107787-AAV8) in PBS

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For those over 45, and certainly those over 60, a glutathione boosting program may be beneficial, as it is critical to overall health and no one is immune to the production declines that come with age

For this subset of OA patients, targeting GPX4 or ferroptosis appears to be a more specific approach and should arguably be regarded as a disease-modifying strategy