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Reassure based on current evidence (no excess malformation risk)

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Stefanski, A

Although almost all the extracts showed variable activity, a selection criterion was introduced based on their in vitro activity (higher activity and lowest standard deviation) and on known information on the use of each plant in the treatment of cardiovascular events

The best human sleep studies on DSIP date from the 1980s and 1990s, with sample sizes typically under 20 subjects and no modern RCT replication, placing overall evidence confidence at Low to Very Low