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3 Labeling for orforglipron and related agents includes warnings for acute pancreatitis, gallbladder disease, acute kidney injury (often secondary to dehydration), hypersensitivity reactions, and diabetic retinopathy complications

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These salutary actions have been observed in numerous rodent diabetes models that usually employed high or near-continuous GABA doses

Clinical trials show that it delivers a weight loss of around 12.4% for those on the maximum dose