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To investigate the metabolite profile of Down syndrome using the model, we began by increasing by 50% the V max of CBS, since the gene for CBS is on chromosome 21 and is expressed at 150% of normal
These proteins are interesting both in terms of placental and maternal physiology during pregnancy and as biomarkers of placental function since their abundance in the systemic circulation may be influenced by placental release
R.et al (2024)
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