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In addition, recent studies indicate that some drugs routinely used in the treatment of allergies (H1 receptor antagonists) have additional anti-glycooxidant and anti-inflammatory effects, which may offset allergy complications caused by oxidative and carbonyl stress (270)

But that same mechanismespecially slower gastric emptying and changes in gut motilityis also part of why GI side effects are so common

References 1 SmolenJSAletahaDBartonABurmesterGREmeryPFiresteinGSet al

This protein is preferentially expressed in the labyrinth layer of the mouse placenta by the endothelial cells

This flexibility appeals to patients who are sensitive to medication changes or who want more granular control over their treatment