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Tirzepatide targets GLP-1 and GIP receptors, while Retatrutide activates GLP-1, GIP, and glucagon receptors, making it a triple agonist peptide
Cagrilintide (Cagri), a long-acting amylin analogue that targets amylin receptors in the hindbrain, reduces food intake and body weight in mice 21
The receptors for GIP and GLP-1 are both expressed in islet beta cells, explaining their direct insulinotropic effects
doi: 10.3389/fphar.2021.627533
Jung H et al
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