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2012;125:11571170.

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Regulation of serum insulin-like growth factor-I (IGF-I) and IGF binding proteins during rat pregnancy

The animals were treated according to the european community prescriptions [EU (86/609/EEC)], then cycled and mated with fertile males at proestrous on 120 d of age, with a positive vaginal smear for sperm, the day after proestrous indicating d 0 of pregnancy

Meta-analyses indicate context-specific benefit rather than universal advantage, reinforcing the clinical importance of baseline biomarker evaluation before initiating supplementation strategies in otherwise healthy individuals