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Sulfonylurea drugs affect sulfonylurea receptor 1 (SUR 1), which leads to the closure of adenosine triphosphate (ATP)-dependent potassium channels, preventing potassium from leaving the cell and depolarizing the cell membrane, leading to an influx of calcium and triggering insulin release
(2024) 14:e1738
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Although different pathophysiological mechanisms lead to metabolic syndrome, it is associated with obesity through dysfunction of adipose tissue as the main contributor to obesity and subsequent complications
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