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Age-Related Risk: One study conducted in a Russian population found that the breast cancer risk associated with the H63D pathogenic variant increased significantly in women over the age of 57 years, highlighting the importance of hormonal changes and iron accumulation over time
These effects were associated with the modulation of reward-related brain regions (such as the mesolimbic dopamine system), which leads to nicotine aversion
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Wing, Rena R., et al
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