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In nutrient-rich conditions, mTOR remains active, suppressing autophagy initiation, while under stress conditions such as energy deficiency or DNA damage, the activation of AMP-activated protein kinase (AMPK), p53 or inhibition of pathways like PI3K/Akt and ERK reduces mTOR activity, which then releases the inhibition on autophagy and facilitates its initiation (Yang and Klionsky, 2010)
It acts on multiple organs, including the pancreas, brain, and stomach
Consider periodic breaks of 4-8 weeks to assess your baseline without the compound and allow any potential receptor desensitization to reset
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