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(27) Similar but less pronounced benefits were observed with DPP4-I therapy compared to sulfonylureas (HR 0.88, 95% CI: 0.790.97 for DFU risk reduction)

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While treatment with SSRIs may bring their ghrelin levels back to a more normal range, it may not impact their leptin (satiety) levels - though studies addressing these topics have been very small

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However, our data suggest that such inhibitors may have more utility when given in combination with 5FU-based chemotherapy