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Advantages of Semaglutide: Well-established safety and efficacy data from decades of diabetes use Approved dosing pathway: gradual titration from 0.25 mg reduces GI side effects Available at Hartwater Wellness as a cash-pay service with transparent monthly pricing Lower cost than tirzepatide at therapeutic doses Considerations: Modestly lower weight loss ceiling compared to tirzepatide Gastrointestinal side effects (nausea, vomiting, diarrhea) most common during titration Tirzepatide Tirzepatide is a dual GIP/GLP-1 receptor co-agonist

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As expected, the expression levels of SREBF1 and PLIN2 were increased by GSTM2 knockdown and decreased by GSTM2 overexpression (Fig