This process is known as genomic or nuclear response and entails up- and down-regulation of diverse genes associated with cell proliferation, survival, and migration (Musgrove and Sutherland, 2009
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The US Food and Drug Administration (FDA) has not approved the drug for any indication, and regulatory agencies of the United Kingdom, Australia, and New Zealand, among others, have also deemed it illegal to sell
These molecular changes correlated with clinical motor improvements, suggesting a potential disease-modifying effect consistent with other trials showing both motor and cognitive benefits as well as biomarker evidence of enhanced insulin and neurotrophic signaling [32, 55]