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Glucose-induced cAMP elevation in -cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling
Are they worsening
Individual metabolic factors play a significant role
The principal mechanisms underlying this modulation include regulation of hydrolytic enzyme activity, generation of ROS during phagocytosis, chemokine-driven recruitment, formation of neutrophil extracellular traps (NETs), and control of inflammatory cytokine secretion
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