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A comprehensive study analyzing peripheral blood lymphocytes in ME/CFS and Long COVID patients utilized advanced flow cytometry and mass spectrometry to observe aberrations in reactive oxygen species (ROS) clearance pathways

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Senescent cells secrete a range of cytokines, including transforming growth factor- (TGF-), interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-8 (IL-8), collectively termed the senescence-associated secretory phenotype (SASP), which exerts profound effects on the function of adjacent cells and tissues (Takahashi et al., 2018

This matters because tools work best when they match the pattern

Further, subclinical PCO is also relatively difficult to assess in assess in community health care settings and the resulting underreporting in medical records means that the rate that subclinical PCO progresses to later clinically significant PCO is generally understudied