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A triple agonist peptide that targets GIP, GLP-1, and glucagon receptors

Skin thickness increased in both the male and female subjects

For a deeper treatment of the mechanism, see our clinical overview of semaglutide and the broader class of GLP-1 medications for weight loss

Frozen slices 12 mm thick were blocked with PBS + 5% NGS, labeled with a Rat Monoclonal Antibody for CD54eBioKAT-1from eBioscience, Invitrogen diluted 1:200 in blocking buffer, then with an Alexa 488 Goat anti-Rat IgG secondary antibody diluted 1:500 in blocking buffer and counterstained with DAPI, and mounted in Vectashield mounting media for fluorescence