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B12 injections have a well-established safety profile and adverse reactions are very rare

Although promising, most of the published studies have been in animal models rather than large-scale human clinical trials

People who eat little or no animal food, including some vegans and strict vegetarians, may be more likely to have low intake unless they use fortified foods or supplements

it changes how your body manages it

In the blood, about 80% of cobalamin is bound to haptocorrin, forming holohaptocorrin, a complex that has a dual function: (1) holohaptocorrin conveys cobalamin to the liver, where it taken up through endocytosis (mediated by asialoglycoprotein receptor, ASGPR)