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Need for Long-Term Clinical Trials Most trials evaluating liraglutide, semaglutide, tirzepatide, and retatrutide in adolescents have lasted 5672 weeks, which may not be sufficient to assess long-term metabolic, cardiovascular, and developmental effects

The FDA has signaled intent to take enforcement action against certain mass-marketed non-FDA-approved GLP-1 products and has drawn a clear distinction between mass-marketed compounded products and patient-specific compounding that may remain permissible in narrow circumstances

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