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Retatrutide markedly suppressed the expression of pro-inflammatory cytokines (TNF- , caspase-1, and NLRP3) and pro-fibrotic factors (fibronectin, -SMA, and collagen I) in treating diabetic kidney disease (DKD) in db/db mice (54)

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If symptoms persist beyond 812 weeks despite appropriate management, or if they significantly impair quality of life, referral for further assessment may be warranted

GLP-1 receptors are present in two critical portions of this pathway: the ventral tegmental area and nucleus accumbens

10.1016/0163-7258(91)90076-X