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If visible particles remain after dissolution, gentle filtering using sterile laboratory filters may be applied to improve solution clarity without affecting molecular structure

Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption

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NICE-approved weight management pathways, including licensed pharmacotherapy and specialist referral, are the appropriate starting point

Although its available online for research purposes, athletes should avoid its use, as testing positive could result in suspension or disqualification