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The dual receptor targeting in tirzepatide appears to enhance its effectiveness for weight reduction

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Despite knowledge of obesity-related complications in younger adults (increased risk of type 2 diabetes, liver and cardiovascular disease and malignancy), these considerations may be outweighed, in older adults, by concerns regarding weight-loss induced reduction in skeletal muscle and bone mass, and the awareness of the obesity paradox

The difference likely reflects the younger, healthier general obesity population versus TRIUMPH-4's older osteoarthritis cohort