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Approximately three quarters of these patients have other clear signs and symptoms of central nervous system involvement, occasionally with onset and progression in the teenage years (71

Interestingly, FM subjects also have increased serum concentrations of leucine compared to HC 69 , which contrasts with the lower concentrations of isovaleric acid we see in FM subjects

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On the other hand, in the placebo group, no significant changes in terms of weight, serum levels of FBS, insulin concentrations and lipid profile were found (Table 4)

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