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Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges
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The OCR of basal respiration, ATP production, proton leak and maximal respiration was additionally affected by the ex vivo stimulus (p S 0.044)
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For instance, a 2017 review showed that taking L-carnitine for 3 days had no effect on markers of brain function including reaction time, vigilance, immediate memory, and delayed recall in young adults without cognitive impairment
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