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Effects of bitter substances on GI function, energy intake and glycaemia-do preclinical findings translate to outcomes in humans

Setting the Scene: Why the Injectable Era Had a Ceiling The anti-obesity treatment market has become synonymous with one of the most closely watched rivalries in modern pharmaceuticals: Novo Nordisk versus Eli Lilly

Our findings clarify why GLP-1 but not GIP-based therapies are effective in T2D and also provide a mechanism accounting for the increase in basal insulin secretion that is a characteristic feature of the disease (i.e., chronic hyperglycemia leads to reduced K ATP channel activity that leads to stimulation of cell electrical activity, which leads to activation of Gq, thereby resulting in elevated basal insulin secretion)

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"Natural and synthetic forms of insulin-like growth factor-1 (IGF-1) and the potent derivative, destripeptide IGF-1: biological activities and receptor binding." Biochemical and Biophysical Research Communications