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Abarca-Gmez L, Abdeen ZA, Hamid ZA, Abu-Rmeileh NM, Acosta-Cazares B, Acuin C, et al
147 Overexpression of miR-144-3p could downregulate the GSH/GSSG ratio, increase the levels of ROS, Fe 2+ , and ACSL4, promote ferroptosis and thus reduce the metastasis of osteosarcoma cells, while high expression of ZIB1 plays the opposite role, 147 indicating that miR-144-3p and its downstream ZIB1 are involved in the development and metastasis of osteosarcoma mainly by interfering with iron metabolism and redox homeostasis
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GIP receptor activation in the brain engages neural circuits involved in food reward and energy homeostasis
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