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Medically reviewed by Missy Zammichieli, DNP, APRN, FNP-BC Updated March 26, 2026 HEAD-TO-HEAD HOW THEY WORK (AND WHY IT MATTERS) Both medications mimic gut hormones that your body produces naturally after eating

Visible body composition changes, reduced abdominal fat and improved muscle tone, typically become apparent between weeks six and twelve

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When injecting Ozempic in the stomach, choose a spot at least 2 inches away from your belly button and avoid your waistline to prevent clothing rubbing against the injection site and creating irritation