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In sum, a host of pharmacologic agents from novel small molecules to repurposed anesthetic drugs are being utilized to stabilize mitochondria, reduce DAMPs release, and optimize immune cell metabolism during the perioperative period

Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice

The effect of glutathione is limited and thereby it has to be maintained

Calculations with the model show that blood concentrations do not necessarily reflect intracellular concentrations of metabolites

This is a result of oxidative stress, because plasma total GSH content is low in patients with cardiovascular disease