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Because the association between homocysteine levels and cardiovascular disease is stronger at younger ages, age differences at the end of a study could partially explain the discrepancy found in prospective studies but not in retrospective studies

Bosnjak, M

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However, REDEFINE 4 (Feb 2026) found CagriSema did not meet noninferiority versus tirzepatide 15 mg at 84 weeks

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