In rectosigmoid biopsies from patients with constipation-predominant IBS and healthy controls, GLP-1R was significantly downregulated in IBS individuals compared to controls [55]
discussion 249-50
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And as somebody who was as really good at a lot of things, including sports, I wasnt great at sports, you know, but I was active and in that piece, not being able to fix my belly, which was deemed a weight problem but not a health problem, really set me off on a trajectory of things that are so unhealthy that even impact things like my bone health today, and certainly impacted my digestion and definitely impacted my early menstrual cycle, you know, and these sorts of things