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Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders

Ferric maltol is effective in correcting iron deficiency anemia in patients with inflammatory bowel disease: results from a phase-3 clinical trial program

M.BaroneA.RiganoM

Specific intervention scenarios of GLP-1 on cellular energy economics Treatment of diabetes: correcting the "imbalance of energy distribution" The core pathology of type 2 diabetes is insulin resistance and beta cell function failure, which leads to the imbalance of energy distribution: the intake of glucose by muscle and adipose tissue is reduced, the liver gluconeogenesis is increased, and the levels of glucose and FFA in the blood are increased, forming a vicious cycle of "hyperglycemia hyperlipidemia"

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