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The first thing to remember is if you are experiencing Acne flareups, Rosacea fulminans, or any other side effects after taking high doses of Vitamin B6 and B12
There is no human safety data on combined use
You already know you tolerate IV therapy well
Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice
doi:10.1136/JECH-2014-204971 22
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