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While GLP-1R expression in the GI tract is classically ascribed to the myenteric plexus, the highest level of GLP-1R expression in the gut is in the Brunner's glands in the upper duodenum (73, 87)

GLP-1 medicationsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide formulationsmust typically be stored between 2C and 8C before opening

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These cases underscore the importance of careful monitoring and open communication between patients and clinicians regarding the use of complementary therapies

A history of unsuccessful weight loss attemptsincluding diet, exercise, or other medicationsoften makes someone a candidate for GLP-1 therapy