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60 Another trial examined the effects of 100 mg Pycnogenol daily for 12 months in 44 healthy participants aged 5570 years with high oxidative stress levels and compared them with similar individuals who received no Pycnogenol

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The only drawbacks are the unpleasant smell and the price - it's a bit steep for the amount you get

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To keep yourself safe from any adverse effects, take your B12 supplement in the morning or early afternoon to prevent any potential disruption to sleep