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114,115 Mitochondrial NADH supplies NADH dehydrogenase (complex I) with electrons, which along with the electrons obtained from FADH 2 via complex II drive the mitochondrial ETC to generate a proton (H + ) gradient across the IMM for the production of ATP
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Nowadays, while there are newer diabetic medications, healthcare providers still typically prescribe metformin when someone is diagnosed with type-2 diabetes unless metformin is considered a contraindication
Moreover, current drugs may suffer from inadequate selectivity for specific fungal species and significant side effects, which limits their widespread clinical use (Puumala et al., 2024)
