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BMJ 388 , e080679 (2025)

Nucleic acid-based therapeutics for the treatment of central nervous system disorders

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Oral semaglutide can be used as a treatment intensification option even in addition to insulin.[] PIONEER 5 was a randomized, double-blind, placebo-controlled, parallel-group, multicentre, multinational trial that included 324 subjects with T2DM and estimated glomerular filtration rate (eGFR) 3059 mL/min/1.73 m 2 , on stable doses of 12 oral antidiabetic drugs (OADs) (metformin, SU) and/or basal insulin for 90 days randomized to oral semaglutide 14 mg and placebo (1:1)

None of the three compounds have human safety data in pregnancy or breastfeeding, and they are not FDA-approved