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It is still important for patients taking GLP-1 medication to limit muscle wasting through exercise and high-quality protein. Losing muscle can lower metabolic rate and physical strength

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Central nervous system effects may include various degrees of encephalopathy, cognitive and memory deficits, impaired concentration, and diminished executive function

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[6] These are minutes, not hours which is why clinical dosing of both has been once-daily subcutaneous injection, and why any marketing that implies a single injection produces long-lasting circulating peptide activity is misleading