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Riociguat is used to treat pulmonary arterial hypertension (high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (high blood pressure caused by blood clots in the lungs)

It is a synthetic version of the hormone exendin-4, which is found in the saliva of the Gila monster, a venomous lizard native to the southwestern United States.76 Exenatide is composed of 39 amino acids and shares 53% sequence identity to human GLP-1

465 The downregulation of GLP-1R expression may represent a significant contributory factor to the co-occurrence of hypertension and hyperglycemia

The combination supports gut barrier integrity and microbiome health, contributing to long-term digestive and metabolic benefits.*

Marshall, R