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In 2016, concerns regarding retinopathy associated with GLP-1 were first raised in the Semaglutide Unabated Sustainability in Treatment of T2DM (SUSTAIN) 6 trial with semaglutide [89]
Recently, the purpurin analog R162 (an inhibitor of GLUD1) also showed promising results with respect to attenuating the proliferation of breast, NSCLC, and glioma cells in vitro and in patient-derived xenograft mouse models 23
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L-carnitine: the transporter idea L-carnitine is not a fat itself
meningitidis MC58, gdhA expression was particularly increased in response to glucose in vitro , a condition that decreased the expression of TCA cycle genes ( gdhA transcription from gdhA P2 is significantly higher in vitro in meningococcal strains belonging to hypervirulent lines compared to those belonging to carrier lines expressing low levels of GhdR (Pagliarulo et al., 2004) as will be discussed below
