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FIGURE 1 Luteolins physicochemical profile is dominated by its extremely low aqueous solubility, with only 0.020.03 mg/mL dissolving in water at 27 C (Rajhard et al., 2021)

Nausea and vomiting were the most frequently reported side effects, followed by diarrhea (8.6%), fatigue (6.3%), and constipation (5.7%)

Receptor Binding Activity Unlike MT-1, which is selective for MC1R, MT-2 has a broad receptor affinity: MC1R : Stimulates melanogenesis, increasing skin pigmentation [6] MC3R : Plays a role in energy balance and metabolic regulation [7] MC4R : Involved in sexual function and appetite regulation [8] MC5R : Associated with sebaceous gland function [8] Key Differences Between Melanotan 1 and Melanotan 2 Science-Backed Possible Benefits For Melanotan 1 Photoprotection Potential : Laboratory and preclinical studies suggest that MT-1 may increase melanin production