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Due to the limit of available articles at the time of search, the initial search was quite broad with a very narrow final evidence base which mainly resulted in case reports or case series, narrative scoping reviews, or small retrospective cohorts

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however, unlike nicotinic acid, niacinamide does not usually cause the intense flushing reaction (redness/itching) of the skin

It also showed a significant positive correlation with Bristol stool score in all patients and a significant positive correlation with stool frequency in the L-carnitine supplemented group only

The pairing covers both upstream pathways that drive pituitary growth hormone release