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The wild card-to-uncertainty about GLP-1 meds growth will be reimbursement: spending will continue to accelerate with upside if more widely reimbursed, IQVIA projects
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Rather than sitting on the filtering cells of the nephron, the receptor is found mainly in the smooth muscle of the renal vasculature, so much of GLP-1s renal effect is hemodynamic and hormonal rather than a direct action on kidney tubules
While this allows for standardized comparisons, it limits direct inference regarding tirzepatides performance relative to other agents such as semaglutide, which is widely regarded as a benchmark GLP-1 receptor agonist
