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Similarly, excessive ROS production is linked to parthanatos induction triggered by compounds, such as oxaliplatin and deoxypodophyllotoxin, in glioma and oral squamous cell carcinoma cells [157, 158]

Two small interfering RNA (siRNA) oligonucleotides were synthesized corresponding to nucleotides 467-485 (UGGAAGAUCUCCUAACUAA, siRNA-1) and nucleotides 1104-1122 (CUAUGAGACUGCUCUAUCA, siRNA-2) of human CDK5RAP2

Although their efficacy in the treatment of neuropathy is still controversial, the current data indicate that these metals can effectively prevent chemotherapy-induced neurotoxicity in preclinical studies

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