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Given the currently available treatment options for weight management, there is an unmet need for an oral, incretin-based therapy with efficacy similar to that of injectable GLP-1 receptor agonists

Notably, FGF21 analogs have reduced insulin resistance or decreased liver fat in clinical trials 16,26

61,62,63 CDO is highly regulated at the level of protein turnover, as oxidative degradation of cysteine by CDO is highly inducible, 64 and high cysteine levels inhibit CDO ubiquitinylation and reduce its proteasomal degradation

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NTS2 is localized to many of the same brain regions as NTS1 (Mazella et al., 1996