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Field reports show that skin deterioration can partly be avoided if biotin and folic acid are simultaneously administered

Certain populations face higher deficiency risk: vegetarians and vegans (B12 is primarily found in animal products), adults over 50 (decreased stomach acid reduces B12 absorption), individuals with digestive disorders like Crohn's disease or celiac disease, and those taking medications like metformin or proton pump inhibitors

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Retinoids and acids work primarily through exfoliation