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While Ozempic, Wegovy, and Mounjaro are widely known for their weight loss effects, they were originally developed to treat type 2 diabetes
Tesamorelin is a synthetic growth hormone releasing hormone (GHRH) analog that stimulates the pituitary gland to produce and release growth hormone
The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism remains unsettled
Signalling at the gliovascular interface
References: Almandoz, J
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